Cheesy Meatball Sub Casserole Recipe for Comforting Dinners

This easy Meatball Sub Casserole is a shortcut dinner: just assemble in a baking dish and dinner is ready in about 40 minutes.

Meatball Sub Casserole

If you love meatball subs but dread the mess, this casserole version gives you the same comforting flavors — cheesy meatballs, marinara, and soft biscuit pieces — without the fussy assembly. It’s quick, family-friendly, and easy to customize.

• Takes under an hour from start to finish
• Creamy, cheesy, and satisfying
• Uses frozen precooked meatballs to save time
• Vegetables can be tucked in for picky eaters

What You’ll Need

• 1 can Pillsbury Country Style Biscuits
• About 1¼ cups marinara sauce (homemade or store-bought)
• 1 tablespoon garlic powder
• ½ onion, diced
• ½ cup asparagus, trimmed and cut (or another vegetable)
• 1 cup shredded cheese (mozzarella or a blend)
• 25–30 precooked frozen meatballs

How To Make This One-Pan Meatball Sub Casserole

• Preheat the oven to 375°F (190°C).
• Cut each biscuit in half to create smaller pieces.

• Lightly grease a baking dish. Add the biscuit pieces and toss with marinara sauce, garlic powder, diced onion, and asparagus so everything is evenly coated.
• Sprinkle about one-quarter of the shredded cheese over the mixture.

• Arrange the frozen meatballs among the biscuit-and-sauce mixture, pressing them in slightly so they sit securely.
• Add another quarter of the cheese on top of the meatballs.

• Cover the dish with foil and bake for 30 minutes. Remove the foil, scatter the remaining cheese over the top, and bake 10–15 more minutes until the cheese is melted and bubbly and the biscuits are cooked through.
• Let rest a few minutes, then serve warm.

Recipe Variations

• Swap the asparagus and onion for bell peppers, mushrooms, spinach, or zucchini.
• Add fresh herbs like basil or chopped rosemary for extra flavor.
• Use chicken or turkey meatballs instead of beef for a lighter option.

Tips and Notes

• If you prefer crispier biscuit edges, position some pieces so they poke up above the sauce.
• To reduce excess liquid, thaw meatballs slightly before baking or drain any pooled liquid from the sauce.
• Use just half an onion if you want to avoid too much extra moisture in the dish.

Recipe

Meatball Sub Casserole

An easy, family-friendly casserole that brings the flavors of a meatball sub to a single baking dish.

5 from 1 vote

Prep Time: 8 minutes

Cook Time: 40 minutes

Total Time: 48 minutes

Servings: 5 – 6 servings

Equipment

• 9×13-inch baking dish or similar

Ingredients

• 1 can Pillsbury Country Style Biscuits
• 1¼ cup marinara sauce
• 1 tablespoon garlic powder
• ½ onion, diced
• ½ cup asparagus, trimmed
• 1 cup shredded cheese
• 25 to 30 precooked frozen meatballs

Instructions

• Heat oven to 375°F (190°C).
• Cut each biscuit in half.
• Grease a baking dish and add the biscuit pieces. Toss with marinara, garlic powder, diced onion, and asparagus to combine.
• Sprinkle one-quarter of the cheese over the mixture.
• Nestle the meatballs into the baking dish so they sit evenly throughout.
• Add another quarter of the cheese on top of the meatballs.
• Cover with foil and bake 30 minutes. Remove foil, top with remaining cheese, and bake 10–15 minutes more until cheese is melted and biscuits are cooked. Let rest briefly before serving.

Notes

This recipe was tested with precooked frozen beef meatballs, which work well and save time.

Nutrition

Serving: 1serving | Calories: 422kcal

Course: One Pot

Cuisine: Comfort

Author: Carmy

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